Exploring Alternative Medicines in the Treatment of Atherosclerosis: an Insight into Molecular Aspect

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Dr. Zar Chi Thent. Department of Anatomy, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital, 47000, Selangor, Malaysia. Tel: +603 61267299 E-mail: zarrchii@gmail.com

Abe, R., Beckett, J., Abe, R., Nixon, A., Rochier, A., Yamashita, N., Sumpio, B. 2012. Olive oil polyphenols differentially inhibit smooth muscle cell proliferation through a G1/S cell cycle block regulated by ERK1/2. Int J Angiol 21: 69-76. Akhtar, S., Ismail, T., Fraternale, D., Sestili, P. 2015. Pomegranate peel and peel extracts: Chemistry and food features. Food Chem 174: 417-25. Al-Shehabi, T.S., Iratni, R., Eid, A.H. 2016. Antiatherosclerotic plants which modulate the phenotype of vascular smooth muscle cells. Phytomedicine 23(11): 1068-81. Anna, Z., Katarzyna, D., Manuel, M. 2013. Oxidative stress in atherosclerosis: the role of microRNAs in arterial remodeling. Free Radical Bio Med 64: 69-77. Babu, P.V., Si, H., Fu, Z., Zhen, W., Liu, D. 2013. Genistein prevents hyperglycemia-induced monocyte adhesion to human aortic endothelial cells through preservation of the cAMP signaling pathway and ameliorates vascular inflammation in obese diabetic mice. J Nutr 142(4): 724-30. Balentine, D.A., Wiseman, S.A., Bouwens, L.C. 1997. The chemistry of tea flavonoids. Crit. Rev Food Sci Nutr 37: 693-704. Bauriedel, G., Hutter, R., Welsch, U., Bach, R., Sievert, H., Luderitz, B. 1999. Role of smooth muscle cell death in advanced coronary primary lesions: implications for plaque instability. Cardiovasc Res 41: 480-8. Bayan, L., Koulivand, P.H., Gorji, A. 2014. Garlic: a review of potential therapeutic effects. Avicenna J Phytomed 4(1): 1-14. Bhandari, U., Sharma, J.N., Zafar, R. 1998. The protective action of ethanolic ginger (Zingiberofficinale) extract in cholesterol fed rabbits. J Ethnopharmacol 61: 167-71. Benassayag, C., Perrot-Applanat, M., Ferre, F. 2002. Phytoestrogens as modulators of steroid action in target cells. J Chromatogr B Anal Technol Biomed Life Sci 777: 233-48. Bulotta, S., Celano, M., Lepore, S.M., Montalcini, T., Pujia, A. and Russo, D. 2014. Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases. J Translational Med 12(1): 219. Cassidy, A. 2003. Potential risks and benefits of phytoestrogen-rich diets. Int J Vitam Nutr Res 73: 120-6. Cassidy, A., Albertazzi, P., Nielsen, I.L., Hall, W., Williamson, G., Tetens, I., Atkins, S., Cross, H., Manios, Y., Wolk, A., Steiner, C. 2006. Critical review of health effects of soya bean phytoestrogens in post-menopausal women. Proc Nutr Soc 65(01): 76-92. Chan, J.Y., Yuen, A.C., Chan, R.Y., Chan, S.W. 2013. A review of the cardiovascular benefits and antioxidant properties of allicin. Phytother Res 27: 637-46. Chen, Y.M., Ho, S.C., Lam, S.S., Ho, S.S., Woo, J.L. 2003. Soy isoflavones have a favorable effect on bone loss in Chinese postmenopausal women with lower bone mass: a double-blind, randomized, controlled trial. J Clin Endocrinol Metab 88(10): 4740-7. Chen, J.S., Huang, P.H., Wang, C.H., Lin, F.Y., Tsai, H.Y., Wu, T.C., Lin, S.J., Chen, J.W. 2011. Nrf- 2 mediated heme oxygenase-1 expression, an antioxidant-independent mechanism, contributes to anti-atherogenesis and vascular protective effects of Ginkgo biloba extract. Atherosclerosis 214(2): 301-9. Chen, L.Y., Sotoodehnia, N., Buzkova, P., Lopez, F.L., Yee. L.M., Heckbert, S.R., Prineas, R., Soliman, E.Z., Adabag, S., Konety, S., Folsom, A.R. 2013. Atrial fibrillation and the risk of sudden cardiac death: the atherosclerosis risk in communities study and cardiovascular health study. JAMA Int Med 173(1): 29-35. Chen, H., Yao, K., Chang, X., Shim, J.H., Kim, H.G., Malakhova, M., Kim, D.J., Bode, A.M., Dong, Z. 2015. Computational and biochemical discovery of RSK2 as a novel target for epigallocatechin gallate (EGCG). PloS One 10(6): e0130049. Colombo, M.L. 2010. An update on vitamin E, tocopherol and tocotrienol-perspectives. Molecules 15: 2103-13. Covas, M.I., De la Torre, R., Fitó, M. 2015. Virgin olive oil: a key food for cardiovascular risk protection. Br J Nutr 113(S2): S19-S28. Cornwell, T., Cohick, W., Raskin, I. 2004. Dietary phytoestrogens and health. Phytochemistry 65: 995-1016. Creswell, D.C., Brooks, C.C. 1971. Composition, Apparent digestibility and energy evaluation of coconut oil and coconut meal. J Anim Sci 33(2): 366-9. Czerwinska, M.E., Kiss, A.K., Naruszewicz, M. 2014. Inhibition of human neutrophils NEP activity, CD11b/CD18 expression and elastase release by 3,4- dihydroxyphenylethanol-elenolic acid dialdehyde, oleacein. Food Chem 153: 1-8. David, J.R. 1996. Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell–antigen interaction. Proc Natl Acad Sci 56: 72–7. Dayrit, F.M. 2015. The properties of lauric acid and their significance in coconut oil. Journal of the American Oil Chemists’ Society 92(1): 1-15. DebMandal, M., Mandal, S. 2011. Coconut (Cocos nucifera L.: Arecaceae): in health promotion and disease prevention. Asian Pac J Trop Med 4(3): 241-7. Dimitriou, M., Rallidis, L.S., Theodoraki, E.V., Kalafati, I.P., Kolovou, G., Dedoussis, G.V. 2016. Exclusive olive oil consumption has a protective effect on coronary artery disease; overview of the thiseas study. Public Health Nutr 19(6): 1081-7. Dixon, R.A. 2004. Phytoestrogens. Annu Rev Plant Biol 55: 225–61. Ebrahimi, T., Behdad, B., Abbasi, M. A., Rabati, R. G., Fayyaz, A. F., Behnod, V., & Asgari, A. 2015. High doses of garlic extract significantly attenuated the ratio of serum LDL to HDL level in rat-fed with hypercholesterolemia diet. Diagnostic Patho 10: 74. Eyres, L., Eyres, M.F., Chisholm, A., Brown, R.C. 2016. Coconut oil consumption and cardiovascular risk factors in humans. Nutr Revi 74(4): 267-80. Faye, I., Decostanzi, M., Ecochard, Y. and Caillol, S. 2017. Eugenol bio-based epoxy thermosets: from cloves to applied materials. Green Chem 19(21): 5236-42. Feranil, A.B., Duazo, P.L, Kuzawa, C.W., Adair, L.S. 2011. Coconut oil predicts a beneficial lipid profile in pre-menopausall women in thhe Philippines. Asia Pac J Clin Nutr 20(2): 190-5. Fischer, U.A., Carle, R., Kammerer, D.R. 2011. Identification and quantification of phenolic compounds from pomegranate (Punica granatum L.) peel, mesocarp, aril and differently produced juices by HPLC-DAD–ESI/MSn. Food Chem 127: 807-21. Fritz, H., Seely, D., Flower, G., Skidmore, B., Fernandes, R., Vadeboncoeur, S., Kennedy, D., Cooley, K., Wong, R., Sagar, S., Sabri, E. 2013. Soy, red clover, and isoflavones and breast cancer: a systematic review. Plos One 8(11): e81968. Froyen, E.B., Reeves, J.L.R., Mitchell, A.E., Steinberg, F.M. 2009. Regulation of phase II enzymes by genistein and daidzein in male and female Swiss Webster mice. J Med Food 12(6): 1227-37. Gencel, V.B., Benjamin, M.M., Bahou, S.N., Khalil, R.A. 2012. Vascular effects of phytoestrogens and alternative menopausal hormone therapy in cardiovascular disease. Mini Rev Med Chem 12: 149-74. Gil-Izquierdo, A., Penalvo, J.L., Gil, J.I., Medina, S., Horcajada, M.N., Lafay, S., Silberberg, M., Llorach, R., Zafrilla, P., Garcia-Mora, P., Ferreres, F. 2012. Soy isoflavones and cardiovascular disease epidemiological, clinical and-omics perspectives. Curr Pharm Biotechnol 13(6): 624-31. Goedeke, L., Wagschal, A., Fernández-Hernando, C., Näär, A.M. 2016. miRNA regulation of LDL-cholesterol metabolism. Biochmica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids 1861(12): 2047-52. Grassi, D., Desideri, G., Di Giosia, P., De Feo, M., Fellini, E., Cheli, P., Ferri, L., Ferri, C. 2013. Tea, flavonoids, and cardiovascular health: endothelial protection. Am J Clin Nutr 98(6): 1660-6. Gupta, M., Sharma, P., Mazumder, A.G., Patial, V., Singh, D. 2015. Dwindling of cardio damaging effect of isoproterenol by Punica granatum L. peel extract involve activation of nitric oxidemediated Nrf2/ARE signaling pathway and apoptosis inhibition. Nitric Oxide 50: 105-13. Hajirahimkhan, A., Dietz, B.M., Bolton, J.L. 2013. Botanical modulation of menopausal symptoms: mechanisms of action? Planta Med 79: 538-53. Hong, J.W., Yang, G.E., Kim, Y.B., Eom, S.H., Lew, J.H., Kang, H. 2012. Anti-inflammatory activity of cinnamon water extract in vivo and in vitro LPS-induced models. BMC Complement Altern Med 12: 237. Ibarreta, D., Daxenberger, A., Meyer, H.H. 2010. Possible health impact of phytoestrogens and xenoestrogens in food. Apmis 109: 161-84. Ibrahim, A.H., Li, H., Al-Rawi, S.S., Majid, A.S.A., Al- Habib, O.A., Xia, X., Majid, A.M.A. and Ji, D. 2017. Angiogenic and wound healing potency of fermented virgin coconut oil: in vitro and in vivo studies. Am J Transl Res 9(11): 4936. Intahphuak, S., Khonsung, P., Panthong, A. 2010. Anti-inflammator, analgesic, and antipyretic activities of virgin coconut oil. Pharm Biol 48(2): 151-7. Isozaki, T., Tamura, H. 2001. Epigallocatechin gallate (EGCG) inhibits the sulfation of 1-naphthol in a human colon carcinoma cell line, Caco-2. Bio Pharm Bull 24: 1076-8. Jin, S., Cho, K.H. 2011. Water extracts of cinnamon and clove exhibits potent inhibition of protein glycation and anti-atherosclerotic activity in vitro and in vivo hypolipidemic activity in zebrafish. Food Chem 49: 1521-9. Kamato, D., Babaahmadi Rezaei, H., Getachew, R., Thach, L., Guidone, D., Osman, N., Roufogalis, B., Duke, C.C., Tran, V.H., Zheng, W., Little, P.J. 2013. (S)-[6]-Gingerol inhibits TGF-beta-stimulated biglycan synthesis but not glycosaminoglycan hyperelongation in human vascular smooth muscle cells. J Pharm Pharmacol 65: 1026-36. Kang, J.S., Yoon, Y.D., Han, M.H., Han, S.B., Lee, K., Park, S.K., Kim, H.M. 2007. Equol inhibits nitric oxide production and inducible nitric oxide synthase gene expression through down-regulating the activation of Akt. Int Immunopharmacol 7(4): 491-9. Kathryn, J., Moore, F. 2013. Macrophages in atherosclerosis: a dynamic balance. Nat Rev Immunol 13: 709-71. Khan, M., Dhammu, T.S., Matsuda, F., Annamalai, B., Dhindsa, T.S., Singh, I., Singh, A.K. 2015. Targeting the nNOS/peroxynitrite/calpain system to confer neuroprotection and aid functional recovery in a mouse model of TBI. Brain Res 1630: 159-70. Kim, S.H., Hyun, S.H., Choung, S.Y. 2006. Antidiabetic effect of cinnamon extract on blood glucose in db/db mice. J Ethnopharmacol 104: 119-23. Kim, J.W., Jin, Y.C., Kim, Y.M., Rhie, S., Kim, H.J., Seo, H.G., Lee, J.H., Ha, Y.L., Chang, K.C. 2009. Daidzein administration in vivo reduces myocardial injury in a rat ischemia/reperfusion model by inhibiting NF-kappa B activation. Life Sci 84: 227-34. Kim, H.S., Lee, S.H., Byun, Y. and Park, H.D. 2015. 6-Gingerol reduces Pseudomonas aeruginosa biofilm formation and virulence via quorum sensing inhibition. Scientific reports, 5, p.8656. Kim, H.S., Lee, S.H., Byun, Y. and Park, H.D., 2015. 6-Gingerol reduces Pseudomonas aeruginosa biofilm formation and virulence via quorum sensing inhibition. Sci Rep 5: 8656. Kinsella, J.E., Frankel, E.N., German, J.B., Kanner, J. 1993. Possible mechanism for the protective role of antioxidants in wine and plant foods. Food Tech 47: 85-9. Kris-Etherton, P.M., Harris, W.S., Appel, L.J. 2002. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 106(21): 2747-57. Kwon, H.K., Hwang, J.S., So, J.S., Lee, C.G., Sahoo, A., Ryu, J.H., Jeon, W.K., Ko, B.S., Im, C.R., Lee, S.H., Park, Z.Y., Im, S.H. 2010. Cinnamon extract induces tumor cell death through inhibition of NF ĸB and AP1. BMC Cancer 10: 392. Kwon, Y. 2014. Effect of soy isoflavones on the growth of human breast tumors: findings from preclinical studies. Food Sci Nutr 2(6): 613-22. Kwon, H., Lee, J.J., Lee, J.H., Cho, W.K., Gu, M.J., Lee, K.J., Ma, J.Y. 2015. Cinnamon and its components suppress vascular smooth muscle cell proliferation by up-regulating cyclindependent kinase inhibitors. Am J Chin Med 43: 621-36. Lee, J.S., Jeon, S.M., Park, E.M., Huh, T.L., Kwon, O.S., Lee, M.K., Choi, M.S. 2003. Cinnamate supplementation enhances hepatic lipid metabolism and antioxidant defense systems in high cholesterol-fed rats. J Med Food 6: 183-91. Lee, J.S. 2006. Effects of soy protein and genistein on blood glucose, antioxidant enzyme activities, and lipid profile in streptozotocin-induced diabetic rats. Life Sciences 79(16): 1578-84. Lee, M.H., Kwon, B.J., Koo, M.A., You, K.E., Park, J.C. 2013. Mitogenesis of vascular smooth muscle cell stimulated by platelet-derived growth factor-bb is inhibited by blocking of intracellular signaling by epigallocatechin-3-O-gallate. Oxid Med Cell Longev 2013: 827905. Li, M., Liu, J.T., Pang, X.M., Han, C.J., Mao, J.J. 2012. Epigallocatechin-3-gallate inhibits angiotensin II and interleukin-6-induced C-reactive protein production in macrophages. Pharmacol Rep 64: 912-8. Lin, C.M., Hou, S.W., Wang, B.W., Ong, J.R., Chang, H., Shyu, K.G. 2014. Molecular mechanism of (-)-epigallocatechin-3-gallate on balloon injury-induced neointimal formation and leptin expression. J Agric Food Chem 62: 1213-20. Lipińska, L., Klewicka, E. and Sójka, M. 2014. The structure, occurrence and biological activity of ellagitannins: a general review. Acta Sci Pol Technol Aliment 13(3): 289-99. Liu, M., Yanagihara, N., Toyohira, Y., Tsutsui, M., Ueno, S., Shinohara, Y. 2007. Dual effects of daidzein, a soy isoflavone, on catecholamine synthesis and secretion in cultured bovine adrenal medullary cells. Endocrinology 148: 5348-54. Liu, R., Heiss, E.H., Sider, N., Schinkovitz, A., Groblacher, B., Guo, D., Bucar, F., Bauer, R., Dirsch, V.M., Atanasov, A.G. 2015. Identification and characterization of [6]- shogaol from ginger as inhibitor of vascular smooth muscle cell proliferation. Mol Nutr Food Res 59: 843-52. Ludwig, A., Lorenz, M., Grimbo, N., Steinle, F., Meiners, S., Bartsch, C., Stangl, K., Baumann, G., Stangl, V. 2004. The tea flavonoid epigallocatechin-3-gallate reduces cytokineinduced VCAM-1 expression and monocyte adhesion to endothelial cells. Biochem Biophys Res Commun 316: 659-65. Manna, S., Chakraborty, T., Ghosh, B., Chatterjee, M., Panda, A., Srivastava, S., Rana, A., Chatteree, M. 2008. Dietary fish oil associated with increased apoptosis and modulated expression of Bax and Bcl-2 during 7,12- dimethylbenz(alpha) anthracene-induced mammary carcinogenesis in rats. Prostaglandins Leukot Essent Fatty Acids 79(1-2): 5-14. Marina, A.M., Che Man, Y.B., Nazimah, S.A.H., Amin, I. 2009. Antioxidant capacity and phenolic acids of virgin coconut oil. Int J Food Sci Nutr 60(2): 114-23. Martin, D., Song, J., Mark, C., Eyster, K. 2008. Understanding the cardiovascular actions of soy isoflavones: Potential novel targets for antihypertensive drug development. Cardiovasc. Hemato Disord Drug Targets 8: 297-312. Masilamani, M., Wei, J., Sampson, H.A. 2012. Regulation of the immune response by soybean isoflavones. Immunol Res 54: 95-110. Matan, N., Rimkeeree, H., Mawson, A.J., Chompreeda, P., Haruthaithanasan, V., Parker, M. 2006. Antimicrobial activity of cinnamon and clove oils under modifiedatmosphere conditions. Int J Food Microbiol 107: 180-5. Mense, S.M., Hei, T.K., Ganju, R.K., Bhat, H.K. 2008. Phytoestrogens and breast cancer prevention: possible mechanisms of action. Environ Health Perspect 116(4): 426. Messina, M., McCaskill-Stevens, W., Lampe, J.W. 2006. Addressing the soy and breast cancer relationship: review, commentary, and workshop proceedings. J Nat Cancer Inst 98(18): 1275-84. Michel, T., Halabalaki, M., Skaltsounis, A.L. 2013. New concepts, experimental approaches, and dereplication strategies for the discovery of novel phytoestrogens from natural sources. Planta Med 79: 514-32. Mittal, M., Siddiqui, M.R., Tran, K., Reddy, S.P., Malik, A.B. 2014. Reactive oxygen species in inflammation and tissue injury. Antiox Redox Signal 20(7): 1126-67. Moneim, A.E. 2015. Oxidant/antioxidant imbalance and the risk of Alzheimer’s disease. Curr Alzheimer Res 12(4): 335-49. Moreira, C., Silva, A.M., Santos, M.S., Sardão, V.A. 2014. Phytoestrogens as alternative hormone replacement therapy in menopause: What is real, what is unknown? J Steroid Biochem Mol Bio 143: 61-71. Mukherjee, S., Mitra, A. 2009. Health effects of palm oil. J Hum Ecol 26: 197-203. Nakaya, M., Tachibana, H., Yamada, K. 2005. Isoflavone genistein and daidzein up-regulate lps-induced inducible nitric oxide synthase activity through estrogen receptor pathway in raw264. 7 cells. Biochem Pharmacol 71: 108- 14. Nammi, S., Kim, M.S., Gavande, N.S., Li, G.Q., Roufogalis, B.D. 2010 Regulation of lowdensity lipoprotein receptor and 3-hydroxy-3- methylglutaryl coenzyme A reductase expression by Zingiber officinale in the liver of high-fat diet-fed rats. Basic Clin Pharmacol Toxicol 106: 389-95. Nevin KG, Rajamohan T. 2004. Beneficial effects of virgin coconut oil on lipid parameters and in vitro LDL oxidation. Clin Biochem 37(9): 830-5. Nevin, K.G., Rajamohan, T. 2008. Influence of virgin coconut oil on blood coagulation factors, lipid levels and LDL oxidation in cholesterol fed Sprague-Dawley rats. e-SPEN 3(1): e1–e8. Nyadjeu, P., Nguelefack-Mbuyo, E.P., Atsamo, A.D., Nguelefack, T.B., Dongmo, A.B., Kamanyi, A. 2013. Acute and chronic antihypertensive effects of Cinnamomum zeylanicum stem bark methanol extract in L-NAME-induced hypertensive rats. BMC Complement Altern Med 13: 27. Orozco-Sevilla, V., Naftalovich, R., Hoffmann, T., London, D., Czernizer, E., Yang, C., Dardik, A., Dardik, H. 2013. Epigallocatechin-3-gallate is a potent phytochemical inhibitor of intimal hyperplasia in the wire-injured carotid artery. J Vasc Surg 58: 1360-5. Pakrashi, S.C., Achari, B., Majumdar, P.C. 1975. Studies on Indian Medicinal plants: part XXXII. Constituents of Ananas comosus (Linn.) Merr leaves. Indian J Chem 13: 755-6. Pan, J.H., Sukhova, G.K., Yang, J.T., Wang, B., Xie, T., Fu, H., Zhang, Y., Satoskar, A.R., David, J.R., Metz, C.N., Bucala, R., Fang, K., Simon, D.I., Chapman, H.A., Libby, P., Shi, G.P. 2004. Macrophage migration inhibitory factor deficiency impairs atherosclerosis in lowdensity lipoprotein receptor-deficient mice. Circulation 109(25): 3149-53. Park, M.H., Ju, J.W. 2013. Daidzein inhibits carbohydrate digestive enzymes in vitro and alleviates postprandial hyperglycemia in diabetic mice. Euro J Pharma 712(1): 48-52. Paterni, I., Granchi, C., Katzenellenbogen, J.A., Minutolo, F. 2014. Estrogen receptors alpha (ERα) and beta (ERβ): subtype-selective ligands and clinical potential. Steroids 90: 13-29 Pearson, T.A., Blair, S.N., Daniels, S.R., Ecke, R.H., Fair, J.M., Fortmann, S., Franklin, B.A, Goldstein, L.B, Greenlland, P., Grundy, S.M, Hong, Y., Miller, N.H, Lauer, R.M, Ockene, I.S, Sacco, R.L., Sallis, J.F, Smith, S.C., Stone, N.J., Taubert, K.A. 2002. AHA guidelines for primary prevention of cardiovascular disease and stroke: 2002 update: Consensus panel guide to comprehensive risk reduction for adult patients without coronary or other atherosclerotic vascular diseases. Circulation 106: 388-91. Peng, S., Yao, J., Liu, Y., Duan, D., Zhang, X., Fang, J. 2015. Activation of Nrf2 target enzymes conferring protection against oxidative stress in PC12 cells by ginger principal constituent 6-shogaol. Food Funct 6(8): 2813-23. Qin, Y., Shu, F., Zeng, Y., Meng, X., Wang, B., Diao, L., Wang, L., Wan, J., Zhu, J., Wang, J., Mi, M. 2014. Daidzein supplementation decreases serum triglyceride and uric acid concentrations in hypercholesterolemic adults with the effect on triglycerides being greater in those with the GA compared with the GG genotype of ESR-β RsaI. J Nutr 144: 49-54. Raffai, G., Kim, B., Park, S., Khang, G., Lee, D., Vanhoutte, P.M. 2014. Cinnamaldehyde and cinnamaldehyde-containing micelles induce relaxation of isolated porcine coronary arteries: role of nitric oxide and calcium. Int J Nanomed 9: 2557-66. Rafieian-Kopaei, M., Setorki, M., Doudi, M., Baradaran, A., Nasri, H. 2014 Atherosclerosis: process, indicators, risk factors and new hopes. Int J Preventive Medicine 5(8). Rakesh, K., Agrawal, D.K. 2005 Cytokines and growth factors involved in apoptosis and proliferation of vascular smooth muscle cells. Int Immunopharmacol 5(10): 1487-506. Rietjens, I.M., Sotoca, A.M., Vervoort, J., Louisse, J. 2013. Mechanisms underlying the dualistic mode of action of major soy isoflavones in relation to cell proliferation and cancer risks. Mol Nutr Food Res 57: 100-13. Rizvi, S.I., Zaid, M.A. 2001. Intracellular reduced glutathione content in normal and type 2 diabetic erythrocytes: effect of insulin and (-) epicatechin. J Physiol Pharmacol 52: 483-8. Roghani, M., Vaez Mahdavi, M.R., Jalali-Nadoushan, M.R., Baluchnejadmojarad, T., Naderi, G., Roghani-Dehkordi, F., Taghi Joghataei, M., Kord, M. 2013. Chronic administration of daidzein, a soybean isoflavone, improves endothelial dysfunction and attenuates oxidative stress in streptozotocin-induced diabetic rats. Phytother Res 27: 112-7. Ross, R. 1999. Atherosclerosis- an inflammatory disease. N Engl J Med 340: 115-26. Saini, R.K. and Keum, Y.S. 2016. Tocopherols and tocotrienols in plants and their products: A review on methods of extraction, chromatographic separation, and detection. Food Research International 82: 59-70. Sakaruka, K., Nakano, M., Ostuka, F., Ladich, E., Kolodgie, F.D., Virmani, R. 2013. Pathophysiology of atherosclerosis plaque progression. Heart Lung Circ 22: 399-411. Sambanthamurthi, R., Tan, Ya., Sundram, K., Hayes, K.C., Abeywardena, M.Y., Leow, S.S., Sekaran, S.D., Sambandan, T.G., Rha, C.K., Sinskey, A.J., Subramaniam, K., Wahid, M.B. 2011a. Oil palm vegetation liquor: A new source of phenolic bioactives. Briti J Nut 106: 1655-63. Sambanthamurthi, R., Tan, Y.A., Sundram, K., Hayes, K.C., Abeywardena, M.Y., Leow, S.S., Sekaran, S.D., Sambandan, T.G., Rha, C.K., Sinskey, A.J., Subramaniam, K., Fairus, S., Wahid, M.B. 2011b. Positive outcomes ofoil palm phenolics on degenerative diseases in animal models. Brit J Nut 106: 1664-75. Senokuchi, T. 2004. Extracellular signal-regulated kinase and p38 mitogen activated protein kinase mediate macrophage proliferation induced by oxidized low-density lipoprotein. Atherosclerosis 176: 233-45. Setchell, K.D., Brown, N.M., Desai, P., Zimmer- Nechemias, L., Wolfe, B.E., Brashear, W.T., Kirschner, A.S., Cassidy, A., Heubi, J.E. 2001. Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements. J Nut 131(4): 1362S-1375S. Shaikh, S.R., Kinnun, J.J., Leng, X., Williams, J.A., Wassall, S.R. 2015. How polyunsaturated fatty acids modify molecular organization in membranes: insight from NMR studies of model systems. Biochim Biophys Acta 1848(1): 211-9. Shankar, P., Ahuja, S., Tracchio, A. 2013. Coconut oil: A Review. Agro FOOD Industry Hi Tech 24(5). Sharma, S., Singh, M., Sharma, P.L. 2012. Ameliorative effect of daidzein: a caveolin-1 inhibitor in vascular endothelium dysfunction induced by ovariectomy. Indian J Exp Biol 50: 28-34. Shen, Y., Chen, G., Xiao, A., Xie, Y., Liu, L., Cao, Y. 2018. In vitro effect of flaxseed oil and αα-linolenic acid against the toxicity of lipopolysaccharide (LPS) to human umbilical vein endothelial cells. Inflammopharmacology 26(2): 645-54. Sirotkin, A.V., Harrath, A.H. 2014. Phytoestrogens and their effects. Euro J Pharma 741: 230-6. Sirtori, C.R. 2001. Risks and benefits of soy phytoestrogens in cardiovascular diseases, cancer, climacteric symptoms and osteoporosis. Drug Safety 24(9): 665-82. Smith, J.S.C., Allen, J., Blair, S.N., Bonow, R.O., Brass, L.M., Fonarow, G.C., Grundy, S.M., Hiratzka, L., Jones, D., Krumholz, H.M., Mosca, L., Pearson, T., Pfeffer, M.A., Taubert, K.A. 2006. AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update: Endorsed by the National Heart, Lung, and Blood Institute. J Am Coll Cardiol 47: 2130–9. Sosić-Jurjević, B., Filipović, B., Ajdzanović, V., Brkić, D., Ristić, N., Stojanoski, M.M., Nestorović, N., Trifunović, S., Sekulić, M. 2007. Subcutaneously administrated genistein and daidzein decrease serum cholesterol and increase triglyceride levels in male middle-aged rats. Exp Biol Med (Maywood) 232: 1222-7. Sundram, K., Sambanthamurthi, R., Tan, Y.A. 2003. Palm fruit chemistry and nutrition. Asia Pac J Clin Nutr 12: 355-62. Tachjian, A., Maria, V., Jahangir, A. 2010. Use of herbal products and potential interactionsin patients with cardiovascular diseases. J Am Coll Cardiol 55: 515-25. Tie, L., An, Y., Han, J., Xiao, Y., Xiaokaiti, Y., Fan, S., Liu, S., Chen, A.F., Li, X. 2013. Genistein accelerates refractory wound healing by suppressing superoxide and foxo1/inos pathway in type 1 diabetes. J Nutr Biochem 24: 88-96. Törmälä, R., Appt, S., Clarkson, T.B., Groop, P.H., Rönnback, M., Ylikorkala, O., Mikkola, T.S. 2008. Equol production capability is associated with favorable vascular function in postmenopausal women using tibolone; no effect with soy supplementation. Atherosclerosis 198(1): 174-8. Valcic, S., Timmermann, B.N., Alberts, D.S., Wachter, G.A., Krutzsch, M., Wymer, J., Guillen, J.M. 1996. Inhibitory effect of six green tea catechins and caffeine on thegrowth of four selected human tumor cell lines. Anticancer Drugs 7: 461-8. Van Der Burg, B., Rutteman Gerard, R., Blankenstein Marinus, A., De Laat Siegfried, W., Van Zoelen Everardus, J.J. 1988. Mitogenic stimulation of human breast cancer cells in a growth factor defined medium: synergistic action of insulin and estrogen. J Cell Physiol 134: 101-8. Veazie, M.A., Galloway, J.M., Matson-Koffman, D., LaBarthe, D.R., Brownstein, J.N., Emr, M., Bollton, E., Freund, E.J., Fulwood, R., Guyton- Krishnan, J., Hong, Y., Lebowitz, M., Ochiai, E., Schoeberl, M., Robertson, R.M. 2005. Taking the initiative: implementing the American Heart Association guide for improving cardiovascular health at the community level: healthy people 2010 heart disease and stroke partnership community guideline implementation and best practices workgroup. Circulation 112: 2538-54. Vitale, D.C., Piazza, C., Melilli, B., Drago, F., Salomone, S. 2013. Isoflavones: estrogenic activity, biological effect and bioavailability. Eur J Drug Metab Pharmacokinet 38: 15-25. Wadhera, R.K., Steen, D.L., Khan, I., Giugliano, R.P., Foody, J.M. 2016. A review of low-density lipoprotein cholesterol, treatment strategies, and its impact on cardiovascular disease morbidity and mortality. J Clini Lipidol 10(3): 472-89. Wallock-Richards, D., Doherty, C.J., Doherty, L., Clarke, D.J., Place, M., Govan, J.R., Campopiano, D.J. 2014. Garlic revisited: antimicrobial activity of allicin-containing garlic extracts against Burkholderia cepacia complex. PLoS One 9(12): 112726. Wang, C., Harris, W.S., Chung, M., Lichtenstein, A.H., Balk, E.M., Kupelnick, B., Jordan, H.S., Lau, J. 2006. n− 3 Fatty acids from fish or fishoil supplements, but not α-linolenic acid, benefit cardiovascular disease outcomes in primaryand secondary-prevention studies: a systematic review. Am J of Clin Nutr 84(1): 5-17. Wang, Q., Ge, X., Tian, X., Zhang, Y., Zhang, J., Zhang, P. 2013. Soy isoflavone: The multipurpose phytochemical (Review). Biomed Reports 1(5): 697-701. Wang, X., Wu, J., Chiba, H., Umegaki, K., Yamada, K., Ishimi, Y. 2003. Puerariae radix prevents bone loss in ovariectomized mice. J Bone Miner Metab 21: 268-75. Wen-Harn, P., Benjamin N.C. 1995. Plasma lipid profiles and epidemiology of atherosclerotic diseases in Taiwan – a unique experience. Atherosclerosis 118(2): 258-95. Widmer, R.J., Freund, M.A., Flammer, A.J., Sexton, J., Lennon, R., Romani, A., Mulinacci, N., Vinceri, F.F., Lerman, L.O., Lerman, A. 2013. Beneficial effects of polyphenol-rich olive oil in patients with early atherosclerosis. Eur J Nutr 52(3): 1223-31. Williamson-Hughes, P.S., Flickinger, B.D., Messina, M.J., Empie, M.W. 2006. Isoflavone supplements containing predominantly genistein reduce hot flash symptoms: a critical review of published studies. Menopause 13(5): 831-9. Wong, K.H., Li, G.Q., Li, K.M., Razmovski- Naumovski, V., Chan, K. 2011. Kudzu root: Traditional uses andpotential medicinal benefits in diabetes and cardiovascular diseases. J Ethnopharmacol 134: 584-607. World Health Organization. 2015. Country statistics and global health estimates. World Health Statistics. Xiang, Q., Lin, G., Xu, J., Zheng, S., Chen, S., Zhou, K., Wang, T. 2012. The role of caveolin1 and sprouty1 in genistein’s regulation of vascular smooth muscle cell and endothelial cell proliferation. J Nutr 142(4): 724-30. Xiao-Hua, Y., Yu-Chang, F., Da-Wei, Z., Kai, Y., Chao-Ke, T. 2013. Foam cells in atherosclerosis. Clin. Chim Acta 424: 245–52. Yanagihara, N., Zhang, H., Toyohira, Y., Takahashi, K., Ueno, S., Tsutsui, M., Takahashi, K. 2014. New insights into the pharmacological potential of plant flavonoids in the catecholamine system. J Pharmacol Sci 124: 123-8. Yang, J., Han, Y., Chen, C., Sun, H., He, D., Guo, J., Jiang, B., Zhou, L., Zeng, C. 2013. EGCG attenuates high glucose-induced endothelial cell inflammation by suppression of PKC and NF-kappaB signaling in human umbilical vein endothelial cells. Life Sci 92: 589-97. Yates, C.M., Tull, S.P., Madden, J., Calder, P.C., Grimble, R.F., Nash, G.B., Rainger, G.E. 2011. Docosahexaenoic Acid Inhibits the Adhesion of Flowing Neutrophils to Cytokine Stimulated Human Umbilical Vein Endothelial Cells–3. J Nutr 141(7): 1331-4. Yi, L., Jin, X., Chen, C.Y., Fu, Y.J., Zhang, T., Chang, H., Zhou, Y., Zhu, J.D., Zhang, Q.Y., Mi, M.T. 2011. Chemical structures of 4-oxo-flavonoids in relation to inhibition of oxidized low-density lipoprotein (LDL)- induced vascular endothelial dysfunction. Int J Mol Sci 12: 5471-89. Yin, Y., Sui, C., Meng, F., Ma, P., Jiang, Y. 2017. The omega-3 polyunsaturated fatty acid docosahexaenoic acid inhibits proliferation and progression of non-small cell lung cancer cells through the reactive oxygen species-mediated inactivation of the PI3K/Akt pathway. Lipids Health Dis 16(1): 87. Younes, M., Honma, N. 2011. Estrogen receptor β. Arch Pathol Lab Med 135: 63-6. Yu, E., Calvert, P.A., Mercer, J.R., Harrison, J., Baker, L., Figg, N.L., Kumar, S., Wang, J.J., Hurst, L.A., Obaid, D.R., Logan, A., West, N.E., Clarke, M.C., Vidal-Puig, A., Murphy, M.P., Bennet, M.R. 2013. Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes, and correlates with higher risk plaques in humans. Circulation 128(7): 702-12. Zarfeshany, A., Asgary, S., Javanmard, S.H. 2014. Potent health effects of pomegranate. Adv Biomed R 3(1): 100. Zhang, H.P., Zheng, F.L., Zhao, J.H., Guo, D.X., Chen, X.L. 2013. Genistein inhibits ox-LDL-induced VCAM-1, ICAM-1 and MCP-1 expression of HUVECs through heme oxygenase-1. Arch Med Res 44(1): 13-20. Zhang, H.P., Zhao, J.H., Yu, H.X., Guo, D.X. 2016. Genistein ameliorated endothelial nitric oxidase synthase uncoupling by stimulating sirtuin-1 pathway in oxi-LDL-injured HUVECs. Env Toxi Pharma 42: 118-24 Zheng, J.S., Hu, X.J., Zhao, Y.M., Yang, J., Li, D. 2013. Intake of fish and marine n-3 polyunsaturated fatty acids and risk of breast cancer: metaanalysis of data from 21 independent prospective cohort studies. BMJ 346: 1-10.