Biological Markers Associated Osteoarthritis

Osteoarthritis is the most common degenerative joint disease that develops in the elderly. The worldwide prevalence continues to rise, leading to pain and disability in older ages. Osteoarthritis can be diagnosed by using plain film X-ray combined with clinical appearance and structural features. The imbalance between cartilage synthesis and degradation has been explained in the development of osteoarthritis, which  is  associated  with  chondrocyte  death.  There  are  many  cytokines  and biological markers related to the disease. The present review provides a background and  discusses  the  known  biological  markers  that  are  related  to  developing osteoarthritis.  These  include  advance  glycation  end  products,  glutathione  and glycosaminoglycans.