Effect of Regulated Type-2 Diabetes Mellitus on the Ocular Surface

Diabetes Mellitus and Ocular Surface
Vol. 19 No. 1 : 2024 (283-291)

ercan ze ercan ze

Abstract
The aim of this study was to see whether well-regulated Type-2 diabetes mellitus (DM) under than 10 years impacted meibography and tear film break-up time. DM (n=45) and normal subjects (n=45) were recruited. Two years’ mean glycated hemoglobin data were calculated as the regulation indicator. Eye examination followed by noninvasive tear break‑up time (NTBUT) measurement and then meibography were conducted. Regression analyses corrected for age and gender were used for comparisons between groups. Pearson correlation analysis was used to examine the linear relationship between NTBUT and meibomian gland loss to mean glycated hemoglobin.  A value of p<0.05 was considered statistically significant. The meiboscale comparisons within groups did not show any statistical difference. The mean meibomian gland loss comparisons between groups for the right lower eyelid (r=0.017, p=0.69), right upper eyelid (r=0.04 p=0.24), left lower eyelid (r=0.009, p=0.68) and left upper eyelid (r=0.027, p=0.13) were all similar. NTBUT for right and left eye were similar between groups (p=0.69 and p=0.36 respectively). Pearson’s correlation did not show any significant correlation between glycated hemoglobin, NTBUT and gland loss. In conclusion, it was found that patients with less than 10-year disease duration under DM regulation had similar ocular surfaces to normal subjects.
Keywords : Diabetes mellitus, eye lids, ocular surface, ophthalmological diagnostic techniques, tears,
Abstrak
Tujuan kajian ini adalah untuk melihat sama ada diabetes melitus jenis 2 yang terkawal dengan baik yang kurang daripada 10 tahun memberi kesan kepada meibografi dan masa pecah filem air mata. Pesakit diabetes (n=45) dan subjek normal (n=45) telah direkrut. Data purata hemoglobin glikat dua tahun dianggap sebagai penanda pengawalan. Pemeriksaan mata diikuti dengan pengukuran masa pecah filem air mata tanpa invasif (NTBUT) dan kemudian meibografi telah dilakukan. Analisis regresi yang diselaraskan dengan umur dan jantina digunakan untuk membandingkan antara kumpulan. Analisis korelasi Pearson digunakan untuk mengkaji hubungan linear antara NTBUT dan kehilangan kelenjar meibomian terhadap purata hemoglobin glikat. Nilai p<0.05 dianggap signifikan secara statistik. Perbandingan skala meibum dalam kumpulan tidak menunjukkan perbezaan statistik. Perbandingan kehilangan kelenjar meibomian purata antara kumpulan untuk kelopak mata bawah kanan (r=0.017, p=0.69), kelopak mata atas kanan (r=0.04 p=0.24), kelopak mata bawah kiri (r=0.009, p=0.68) dan kelopak mata atas kiri (r=0.027, p=0.13) adalah serupa. NTBUT bagi mata kanan dan kiri adalah serupa antara kumpulan (p=0.69 dan p=0.36 masing-masing). Korelasi Pearson tidak menunjukkan sebarang korelasi yang signifikan antara hemoglobin glikat, NTBUT dan kehilangan kelenjar. Kesimpulannya, ia didapati bahawa pesakit dengan tempoh penyakit kurang daripada 10 tahun di bawah kawalan diabetes mempunyai permukaan mata yang serupa dengan subjek normal.  
Kata Kunci : Air mata, diabetes melitus, kelopak mata, permukaan okular, teknik diagnostik oftalmologi,

Correspondance Address
Zeynep Eylul Ercan. Yıldırım Beyazıt University Yenimahalle Education and Training Hospital Department of Ophthalmology, Ankara, 06900, Turkey. Tel: +90 (312) 587 20 00 Email: eylulercan@doctor.com