Effect of Caffeic Acid Phenethyl Ester on Wound Healing: A Systematic Review
Caffeic Acid and Skin Wound Healing
Abstract
Caffeic acid, a naturally occurring organic compound, possesses antioxidant and anti-inflammatory properties, along with its derivatives. This systematic review aimed to evaluate the effect of caffeic acid and its derivatives on oxidative stress and inflammatory response in cutaneous wound healing. This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. Searches were performed in PubMed, Scopus, and Ovid MEDLINE. Articles published between 2000 and June 2022, with seven articles meeting the inclusion criteria were retrieved. The articles constituted in-vivo studies that utilised caffeic acid phenethyl ester (CAPE) as the therapeutic agent in three types of cutaneous wound including full-thickness burn injury (n=4), two incisional wounds, and one pressure ulcer. CAPE scavenged reactive oxidative species and reduced lipid peroxidation, superoxide dismutase, nitrotyrosine, malondialdehyde, catalase, xanthine oxidase, and nitric oxide levels. The treated injured area revealed enhanced granulation tissue formation, vascularisation, and collagenisation as well as long-term effects of CAPE as evidenced by reduced myofibroblast amount, CD68-positive macrophages, and increased collagen deposition. The systematic review emphasised how antioxidant and anti-inflammatory effects of CAPE could improve the process of wound healing, suggesting its substantial potential for clinical applications in this domain.
Keywords :
Antioxidant,
caffeic acid phenethyl ester,
thermal injuries,
Abstrak
Asid kafeik, sebatian organik yang wujud secara semulajadi, mempunyai sifat antioksidan dan anti-radang, bersama dengan bahan terbitannya. Kajian sistematik ini bertujuan untuk menilai kesan asid kafeik dan bahan terbitannya terhadap tekanan oksidatif dan tindak balas keradangan dalam penyembuhan luka kulit. Kajian ini dijalankan mengikut panduan Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020. Carian dilakukan di PubMed, Scopus, dan Ovid MEDLINE. Artikel yang diterbitkan antara tahun 2000 dan Jun 2022, dengan tujuh artikel yang memenuhi kriteria inklusi telah dipilih. Artikel-artikel tersebut merupakan kajian in-vivo yang menggunakan asid kafeik fenetil ester (CAPE) sebagai agen terapeutik dalam tiga jenis luka kulit termasuk kecederaan melecur berketebalan penuh (n=4), dua luka insisi dan satu ulser tekanan. CAPE menurunkan kadar spesies oksidatif reaktif dan mengurangkan peroksidasi lipid, superoksida dismutase, nitrotirosin, malondialdehid, katalase, xanthine oksidase, dan paras nitrik oksida. Kawasan luka yang dirawat menunjukkan peningkatan pembentukan tisu granulasi, vaskularisasi, dan kolagenisasi serta kesan jangka panjang CAPE seperti yang dibuktikan oleh pengurangan jumlah miofibroblas, makrofag CD68-positif, dan peningkatan penyerapan kolagen. Kajian sistematik ini menekankan bagaimana kesan antioksidan dan anti-radang CAPE dapat mempercepatkan penyembuhan luka di mana CAPE juga berpotensi besar untuk diaplikasikan dalam penggunaan klinikal.
Kata Kunci :
Antioksidan,
asid kafeik fenetil ester,
kecederaan haba,
Correspondance Address
Dr Nahdia Afiifah Abdul Jalil. Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia. Tel: +603 9145 8605 Email: nahdia.afiifah@ukm.edu.my
