Basal Cell Carcinoma Arising from an Epidermal Naevus
BCC from Epidermal Naevus
Abstract
Epidermal naevus is a congenital cutaneous hamartoma with a benign course. We highlight a rare case of epidermal naevus with concurrent basal cell carcinoma. A 79-year-old male had a skin biopsy at our centre for an enlarging skin nodule within a linear papular lesion measuring 2 x 4 cm at the left side of his neck, which was later diagnosed as basal cell carcinoma arising from an epidermal naevus. PIK3CA mutation is attributed to basal cell carcinoma which suggests the basal cell carcinoma component is independent of the epidermal naevus component. Clinicians and pathologists must be aware of possible malignant changes that might arise in an epidermal naevus.
Keywords :
basal cell carcinoma,
BCC,
epidermal naevus,
Abstrak
Epidermal naevus adalah hamartoma kulit kongenital yang benigna. Kami mengetengahkan kes yang jarang ditemui iaitu epidermis naevus dengan transformasi malignan untuk karsinoma sel basal. Seorang lelaki berusia 79 tahun telah dibiopsi untuk nodul kulit berukuran 2 x 4 cm yang timbul di dalam lesi papular linear berukuran 2 x 4 cm di sebelah kiri lehernya. Nodul itu kemudiannya disahkan sebagai karsinoma sel basal yang timbul daripada epidermal naevus. Mutasi gen PIK3CA mutasi dikaitkan dengan karsinoma sel basal, yang menunjukkan komponen sel karsinoma basal adalah bebas daripada komponen epidermis naevus. Doktor klinikal dan pakar patologi perlu sedar kemungkinan perubahan malignan yang mungkin timbul dalam epidermal naevus.
Kata Kunci :
BCC,
epidermal naevus,
karsinoma sel basal,
Correspondance Address
Fazarina Mohammed. Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia. Tel: +603-91459482 Fax: 03-91459485 E-mail: fazarina.m@gmail.com.
