Quantification of Bone Histomorphometric Parameters Using the Weibel Technique in Animals
Quantification of Bone Histomorphometric Parameters
Vol. 11 No. 2 : 2016 (278-288)
Abstract
Bone histomorphometric measurements are required to understand the efficacy of treatment on bone remodelling. Previous studies used the Weibel technique as a quantitative stereological method to determine bone cellular and dynamic changes. However, there was no description on how this technique was applied. This studyaimed to provide a full picture about the utilization of the Weibel technique to measure static and dynamic bone histomorphometric indices. Technical expertise, processing of bone samples, randomization of the trabecular sections and an adequate number of analysed images for each section are required to achieve reliable results with a low possibility of errors.
Keywords :
bone histomorphometry,
Bone remodelling,
Weibel technique,
Correspondance Address
Ima-Nirwana Soelaiman, Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia. Tel: +603-91459579 Fax: +603-91456634 Email: imasoel@medic.ukm.my
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