Primary bone marrow lymphoma (PBML) is a rare condition. Most PBMLs are B-cell non-Hodgkin lymphomas (NHLs), where predominated by the diffuse large B-cell lymphomas (DLBCLs). Non-Hodgkin lymphomas affects extranodal sites in one-third of cases. Secondary central nervous system lymphoma (SCNSL) is a rare state which is defined as secondary central nervous system (CNS) involvement in patients with systemic lymphoma. In this report, we described a case of primary bone marrow lymphoma with secondary involvement of the CNS. Patient presented with neurological deficit. Peripheral blood film showed presence of abnormal mononuclear cells. Histopathological examination of the brain tissue showed features of DLBCL with CD10 positivity. Bone marrow examination showed presence of lymphoma cells. He was commenced with Rituximab, methotrexate, vincristine and procarbazine (R-MPV). However, he succumbed after two cycles of chemotherapy.
Primary Bone Marrow Lymphoma with Secondary Central Nervous System Involvement: A Case Report
Abstrak
Limfoma sumsum tulang primer (PBML) ialah keadaan yang jarang berlaku. Kebanyakan PBML ialah limfoma jenis ‘non-Hodgkin lymphoma’ (NHL), di mana ‘diffuse large B-cell lymphoma’ (DLBCL) kerap dijumpai. Non-Hodgkin lymphoma dijumpai di luar nodal dalam satu pertiga kes. Limfoma sistem saraf pusat sekunder (SCNSL) ialah keadaan yang jarang berlaku dan ditakrifkan sebagai penglibatan sistem saraf pusat sekunder (CNS) dalam kalangan pesakit yang mempunyai limfoma sistemik. Dalam laporan ini, kami menerangkan kes limfoma sumsum tulang primer dengan penglibatan sekunder CNS. Pesakit menunjukkan defisit neurologi. Filem darah peranti persisian menunjukkan kehadiran sel mononuklear yang tidak normal. Pemeriksaan histopatologi tisu otak menunjukkan ciri-ciri DLBCL dan positif untuk CD10. Pemeriksaan sumsum tulang menunjukkan kehadiran sel limfoma. Pesakit diberikan rawatan dengan Rituximab, methotrexate, vincristine dan procarbazine (R-MPV). Walau bagaimanapun, dia meninggal dunia selepas dua kitaran rawatan kemoterapi.
Abstract
|
|
|
Related Images
