The most prevalent type of autoimmune inflammatory arthritis is rheumatoid arthritis (RA). Sex hormones are strongly associated in the pathogenesis and progression of RA. Hence, the core objective of this study was to compare the clinical features of RA among men and women. We consecutively recruited 23 men and 23 age-matched women with RA from our rheumatology clinic. Subjects were evaluated for their disease activities, radiographic joint damages and functional capacities. The above assessment was performed using DAS-28, Modified Sharp Score (MSS) and European League Against Rheumatism (EULAR) response criteria; respectively. The mean age for the male and female patients were 60.87 + 12.5 and 60.70 + 11.73, respectively. We found that the female subjects had significantly higher c-reactive protein (CRP) levels (p=0.05). The HAQ-DI(p<0.02) and MSS scores (p<0.001) of women were substantially higher than those of males. HAQ-DI and MSS remained to be independently associated with female gender in multivariate analysis, with p values of 0.017 and 0.014, respectively. The findings of this study suggested that in RA, compared to men, women had more severe joint damage and functional disability.
Gender Differences in Clinical Characteristics of Rheumatoid Arthritis
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Abstrak
Artritis reumatoid (RA) adalah bentuk arthritis radang autoimun yang paling lazim. Hormon seks sangat dikaitkan dengan patogenesis dan perkembangan RA. Oleh itu, tujuan kajian ini adalah untuk membandingkan ciri klinikal RA di kalangan lelaki dan wanita. Kami merekrut 23 orang lelaki dan 23 orang wanita secara berturut-turut mengikut padanan umur dengan RA dari klinik reumatologi. Semua subjek dinilai untuk aktiviti penyakit mereka berdasarkan kriteria DAS-28, kerosakan sendi radiografi berdasarkan Modified Sharp Score (MSS), kapasiti fungsional berdasarkan Soal Selidik Penilaian Kesihatan – Indeks Kecacatan (HAQ-DI) dan responsif rawatan menggunakan kriteria tindak balas Liga Eropah Menentang Rheumatisme (EULAR). Purata umur bagi pesakit lelaki dan wanita masing-masing ialah 60.87 + 12.5 dan 60.70 + 11.73. Kami mendapati bahawa subjek wanita mempunyai tahap "c-reactive protein" (CRP) yang jauh lebih tinggi (p = 0.05). Skor HAQ-DI (p<0.02) dan MSS (p<0.001) wanita jauh lebih tinggi daripada lelaki. HAQ-DI dan MSS kekal dikaitkan secara bebas dengan jantina wanita dalam analisis multivariat, dengan nilai p masing-masing ialah 0.017 dan 0.014. Hasil kajian ini menunjukkan bahawa wanita mengalami kerosakan sendi dan kecacatan fungsi yang lebih teruk dengan penyakit arthritis berbanding lelaki.
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