STAT6 is a Useful Immunohistochemical Adjunct for the Diagnosis of Solitary Fibrous Tumour
STAT6 in Solitary Fibrous Tumour
Vol. 14 No. 2 : 2019 (41-49)
Abstract
Solitary fibrous tumour (SFT) is a fibrotic neoplasm, also previously designated as hemangiopericytoma. STAT6 is a protein for signal tranducers and activators of transcription (STAT) family which is involved in immune function and early cell growth. Oncogenic alteration of STAT6 plays an important role for specific driver for tumour genesis of solitary fibrous tumour via NAB2-STAT6 fusion gene. The aim of the study was to compare and evaluate STAT6 expression between SFT and other soft tissue histological mimics. We evaluated a total of 30 cases material formalin fixed paraffin embedded tissue block previously diagnosed SFT cases (n=14) and soft tissue tumours mimic cases (n=16) over period of 15 years. Fourteen SFT cases (100%) showed nuclear expression of STAT6, which was diffuse and intense. All other tumour types were negative for STAT6, except for one case of dedifferentiated liposarcoma, one gastrointestinal stromal tumour and one spindle cell lipoma, which showed weak non-specific cytoplasmic staining. Nuclear STAT6 expression is useful and reliable as adjunctive marker for solitary fibrous tumour when the diagnosis is inconclusive by conventional methods.
Keywords :
Immunohistochemistry,
solitary fibrous tumour (SFT),
STAT6,
Correspondance Address
Dr. Reena Rahayu Md Zin. Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia. Tel: +603-9145 5359 Email: reenarahayu@ppukm.ukm.edu.my, ayureena@gmail.com
References
Cheah, A.L., Billings, S.D., Goldblum, J.R., Carver, P., Tanas, M.Z., Rubin, B.P. 2014. STAT6 rabbit monoclonal antibody is a robust diagnostic tool for the distinction of solitary fibrous tumour from its mimics. Pathology 46(5): 389-95.
Chmielecki, J., Crago, A.M., Rosenberg, M., O’Connor, R., Walker, S.R., Ambrogio, L., Auclair, D., McKenna, A., Heinrich, M.C., Frank, D.A., Meyerson, M. 2013. Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors. Nat Genet 45(2): 131-2.
Demicco, E.G., Harms, P.W., Patel, R.M., Smith, S.C., Ingram, D., Torres, K., Carskadon, S.L., Camelo-Piragua, S., McHugh, J.B., Siddiqui, J., Palanisamy, N., Lucas, D.R., Lazar, A.J., Wang, W.L. 2015. Extensive survey of STAT6 expression in a large series of mesenchymal tumors. Am J Clin Pathol 143(5): 672-82.
Doyle, L.A., Vivero, M., Fletcher, C.D., Mertens, F., Hornick, J.L. 2014. Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics. Mod Pathol 27(3): 390-5.
Fletcher, C.D.M., Bridge, J.A., Hogendoorn, P., Mertens, F. 2013. World Health Organization Classification of tumours of soft tissue and bone. 4th. IARC, Lyon
Goldblum, J.R., Weiss, S.W., Folpe, A.L. 2013. Enzinger and Weiss’s Soft Tissue Tumors E-Book. Elsevier Health Sciences.
Hornick, J.L. 2013. Practical Soft Tissue Pathology: A diagnostic approach. 1st Edition. Elsevier
Okui, T., Ibaragi, S., Kawai, H., Sasaki, A. 2019. Solitary fibrous tumor arising in the buccal space. Case Rep Med 2019: Article ID 9459837.
Robinson, D.R., Wu, Y.M., Kalyana-Sundaram, S., Cao, X., Lonigro, R.J., Sung, Y.S., Chen, C.L., Zhang, L., Wang, R., Su, F., Iyer, M.K. 2013. Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing. Nat Genet 45(2): 180-5.
Stout, A.P., Murray, M.R. 1942. Hemangiopericytoma: a vascular tumor featuring Zimmermann's pericytes. Ann Surg 116(1): 26-33
Vogels, R.J., Vlenterie, M., Versleijen-Jonkers, Y.M., Ruijter, E., Bekers, E.M., Verdijk, M.A., Link, M.M., Bonenkamp, J.J., van der Graaf, W.T., Slootweg, P.J., Suurmeijer, A.J., Groenen, P.J., Flucke, U. 2014. Solitary fibrous tumor–clinicopathologic, immunohistochemical and molecular analysis of 28 cases. Diagn Pathol 9: 224.
Yokoi, T., Tsuzuki, T., Yatabe, Y., Suzuki, M., Kurumaya, H., Koshikawa, T., Kuhara, H., Kuroda, M., Nakamura, N., Nakatani, Y. and Kakudo, K. 1998. Solitary fibrous tumour: significance of p53 and CD34 immunoreactivity in its malignant transformation. Histopathology 32(5): 423-32.
Zafar, H., Takimoto, C.H., Weiss, G. 2003. Doege-potter syndrome: hypoglycemia associated with malignant solitary fibrous tumor. Med Oncol 20 (4): 403-8
