Reevaluating the Prognostic Value of Histopathological Parameters in Soft Tissue Sarcoma of the Extremities
HPE Parameters in STS of Extremities
Abstract
Various staging and grading systems aim to correlate morphological and clinical parameters with the prognosis of soft tissue sarcoma. However, the existing literature offers inconsistent findings. This retrospective cross-sectional study investigated the prognostic value of common histopathological parameters in predicting the survival of extremity soft tissue sarcoma patients. The study comprised 122 patients, and it evaluated parameters like tumour necrosis, mitotic count, tumour differentiation score, and tumour margin status. The survival outcomes were analysed concerning these histopathological variables. The 5-year survival rate was 48%, with a median survival of 88 months. Of the patients, 87.7% (n = 107) had tumour-free margins. Statistical analyses, including Kaplan-Meier Survival Analysis and Cox Proportional Hazard regression, revealed that none of these parameters exhibited significant prognostic value (p>0.05). This study found that none of the histopathological parameters examined demonstrate prognostic significance for long-term survival among soft tissue sarcoma patients over a 10-year follow-up period.
Keywords :
Histopathology,
prognosis,
soft tissue malignancy,
survival analysis,
tumour margin,
Abstrak
Pelbagai sistem dan penarafan bertujuan untuk menghubungkan parameter morfologi dan klinikal dengan prognosis sarkoma tisu lembut. Walau bagaimanapun, literatur sedia ada menunjukkan penemuan yang tidak konsisten. Kajian retrospektif ini mengkaji nilai ramalan prognostik parameter histopatologi yang biasa digunakan dalam meramal kelangsungan hidup pesakit sarkoma tisu lembut di anggota badan. Kajian ini melibatkan 122 pesakit dan menilai parameter seperti nekrosis tumor, kiraan mitosis, skor pebezaan tumor, dan status sempadan tumor. Hasil kelangsungan hidup dianalisis berdasarkan pembolehubah histopatologi ini. Kadar kelangsungan hidup 5 tahun adalah 48%, dengan jangka hayat median selama 88 bulan. Di kalangan pesakit, 87.7% (n = 107) mempunyai sempadan bebas tumor. Analisis statistik, termasuk Analisis Kelangsungan Kaplan-Meier dan regresi Bahaya Berkadar Cox, mendapati bahawa tiada satu pun daripada parameter ini menunjukkan nilai prognostik yang signifikan (p>0.05). Kajian ini mendapati bahawa tiada parameter histopatologi yang dikaji menunjukkan kepentingan prognostik terhadap kelangsungan hidup jangka panjang di kalangan pesakit sarkoma tisu lembut selama tempoh pemantauan 10 tahun.
Kata Kunci :
Analisis kelangsungan hidup,
histopatologi,
malignan tisu lembut,
prognosis,
sempadan tumor,
Correspondance Address
Associate Professor Dr. Mohd Ariff bin Sharifudin. Department of Orthopaedics, Traumatology and Rehabilitation, Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), Medical Campus, Jalan Sultan Mahmud, 20400 Kuala Terengganu, Terengganu, Malaysia.
Tel: +609-6275630 / +6019-3352499 Email: ariffsharifudin@unisza.edu.my / dr.ariff.s@gmail.com
