Clinical Presentations of PCOS in Association with Insulin Resistance and Serum Esterase Enzymes: A Case-control Study
Link of Serum Esterase Enzymes with PCOS
Abstract
Polycystic ovarian syndrome (PCOS) is an endocrine-metabolic disease affecting women in their childbearing age. Although, it has a high prevalence (3-10%), the exact etiology is poorly understood. Insulin resistance (IR) is involved in pathophysiology of PCOS, and some esterase enzymes such as butyrylcholinesterase (BuChE) and paraoxonase 1 (PON1) have been found to be affected in IR disorders. The aim of this study was to investigate serum esterase enzymes and their relationship with IR and clinical presentations PCOS. In this case-control study, 56 PCOS and 62 non-PCOS women were enrolled. Demographic and clinical parameters including working, marital, parity and menstrual status, body mass index (BMI), IR, BuChE and PON1 activity were measured and compared between the groups. The marital and parity status of PCOS women were lower than control group. In comparison with control, PCOS women had significantly higher menstrual irregularity, IR and BuChE activity as well as lower PON1 activity. There was a significant correlation between BuChE activity and BMI in PCOS women. When justified by IR, BuChE activity was still higher in PCOS women than control. The results indicate that serum esterase enzyme can be changed in PCOS and IR is most probably involved in these alterations.
Keywords :
Cholinesterase,
insulin resistance; menstrual irregularity; paraoxonase 1; polycystic ovarian syndrome,
Abstrak
Sindrom ovari polisistik (PCOS) ialah penyakit endokrin-metabolik yang mempengaruhi wanita dalam usia subur mereka. Walaupun prevalensinya tinggi (3-10%), etiologi yang tepat masih kurang difahami. Ketahanan insulin (IR) terlibat dalam patofisiologi PCOS, dan beberapa enzim ester seperti butirilkolinesterase (BuChE) dan paraoksonase 1 (PON1) telah ditemui terjejas dalam IR. Tujuan kajian ini adalah untuk mengkaji enzim ester serum dan hubungannya dengan IR dan manifestasi klinikal PCOS. Dalam kajian kes-kawalan ini, 56 wanita dengan PCOS dan 62 wanita tanpa PCOS telah direkrut. Parameter demografi dan klinikal termasuk status bekerja, perkahwinan, jumlah anak dan status haid, indeks jisim badan (BMI), IR, aktiviti BuChE dan PON1 telah diukur dan dibandingkan di antara dua kumpulan. Status perkahwinan dan jumlah anak bagi wanita PCOS adalah lebih rendah berbanding kumpulan kawalan. Berbanding dengan kawalan, wanita PCOS mempunyai ketidakteraturan haid, IR, dan aktiviti BuChE yang signifikan lebih tinggi serta aktiviti PON1 yang lebih rendah. Terdapat korelasi yang signifikan antara aktiviti BuChE dan BMI dalam wanita PCOS. Apabila dibandingkan dengan IR, aktiviti BuChE masih lebih tinggi dalam wanita PCOS berbanding dengan kawalan. Hasil ini menunjukkan bahawa enzim ester serum boleh mengalami perubahan pada PCOS dan IR mungkin terlibat dalam perubahan ini.
Kata Kunci :
etidakteraturan menstruasi; kolinesterase; paraoxonase 1; resistensi insulin; sindrom ovarium policistik,
Correspondance Address
Sara Mostafalou, Associate Professor. Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, 5618953141 Ardabil, Iran. Tel: +98 45 33522437 / +98 9307371247 Email: s.mostafalou@gmail.com, s.mostafalou@arums.ac.ir
