Calculating In-vivo Short-term Precision Error of Dual-Energy X-ray Absorptiometry in Human and Animal: A Technical Report
Short-term Precision Error of DXA
Vol. 15 No. 1 : 2020 (70-77)
Abstract
Bone mineral density (BMD) measurement by dual-energy X-ray absorptiometry (DXA) is important in diagnosing osteoporosis. Precision error of DXA is a useful measure to determine a true change in BMD value. This study aimed to investigate the short-term coefficient of variance of Hologic Discovery QDR Wi DXA machine. The lumbar spine and hip BMD of fifteen healthy volunteers (mean age: 30.67 + 10.41 years) and the whole body BMD of fifteen female Sprague-Dawley rats (aged three months old) were scanned using Hologic Discovery QDR Wi DXA machine. Each volunteer and rat underwent triplicate scans to assess the reproducibility of BMD values. The interval between the scans ranged within 1 to 12 weeks for human subjects. For animal samples, the scans were repeated on the same day after repositioning. The precision error was expressed as a percentage coefficient of variance (%CV). The %CV obtained for lumbar spine and hip BMD for human were 1.8% and 1.2%, respectively. The %CV for whole body BMD of rats was 1.4%. The short-term CV demonstrated for both human and animal in the present study were comparable. The precision error of DXA must be monitored to ensure optimal performance of the device.
Keywords :
bone mineral density,
dual-energy-X-ray absorptiometry,
in vivo,
precision,
Correspondance Address
Chin Kok Yong. Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia. Tel: +603-9145 9573 Email: chinkokyong@ppukm.ukm.edu.my
References
Ammann, P., Rizzoli, R., Slosman, D., Bonjour, J.P. 1992. Sequential and precise in vivo measurement of bone mineral density in rats using dual-energy x-ray absorptiometry. J Bone Miner Res 7(3): 311-6.
Boutsen, Y., Jamart, J., Esselinckx, W., Devogelaer, J.-P. 2001. Primary prevention of glucocorticoid-induced osteoporosis with intravenous pamidronate and calcium: a prospective controlled 1-year study comparing a single infusion, an infusion given once every 3 months, and calcium alone. J Bone Miner Res 16(1): 104-12.
Carey, J.J., Delaney, M.F. 2017. Utility of DXA for monitoring, technical aspects of DXA BMD measurement and precision testing. Bone 104(2017): 44-53.
Casez, J., Muehlbauer, R., Lippuner, K., Kelly, T., Fleisch, H., Jaeger, P. 1994. Dual-energy X-ray absorptiometry for measuring total bone mineral content in the rat: study of accuracy and precision. Bone Miner 26(1): 61-8.
El Maghraoui, A., Roux, C. 2008. DXA scanning in clinical practice. QJM: An International Journal of Medicine 101(8): 605-17.
El Maghraoui, A., Zounon, A.D.S., Jroundi, I., Nouijai, A., Ghazi, M., Achemlal, L., Bezza, A., Tazi, M., Abouqual, R. 2005. Reproducibility of bone mineral density measurements using dual X-ray absorptiometry in daily clinical practice. Osteoporosis International 16(12): 1742-8.
Engelke, K., Glüer, C., Genant, H. 1995. Factors influencing short-term precision of dual X-ray bone absorptiometry (DXA) of spine and femur. Calcif Tissue Int 56(1): 19-25.
Fuleihan, G.E.H., Testa, M.A., Angell, J.E., Porrino, N., Leboff, M.S. 1995. Reproducibility of DXA absorptiometry: a model for bone loss estimates. J Bone Miner Res 10(7): 1004-14.
Ho-Pham, L.T., Nguyen, U.D., Pham, H.N., Nguyen, N.D., Nguyen, T.V. 2011. Reference ranges for bone mineral density and prevalence of osteoporosis in Vietnamese men and women. BMC Musculoskelet Disord 12(1): 182.
Karahan, S., Kincaid, S.A., Lauten, S.D., Wright, J.C. 2002. In vivo whole body and appendicular bone mineral density in rats: a dual energy X-ray absorptiometry study. Comp Med 52(2): 143-51.
Kim, H.-S., Yang, S.-O. 2014. Quality control of DXA system and precision test of radio-technologists. J Bone Metab 21(1): 2-7.
Limpaphayom, K.K., Taechakraichana, N., Jaisamrarn, U., Bunyavejchevin, S., Chaikittisilpa, S., Poshyachinda, M., Taechamahachai, C., Havanond, P., Onthuam, Y., Lumbiganon, P. 2001. Prevalence of osteopenia and osteoporosis in Thai women. Menopause 8(1): 65-9.
Lochmüller, E., Jung, V., Weusten, A., Wehr, U., Wolf, E.Eckstein, F. 2001. Precision of high-resolution dual energy x-ray absorptiometry measurements of bone mineral status and body composition in small animal models. Eur Cells Mater 1(2001): 43-51.
Maggio, D., McCloskey, E., Camilli, L., Cenci, S., Cherubini, A., Kanis, J., Senin, U. 1998. Short-term reproducibility of proximal femur bone mineral density in the elderly. Calcif Tissue Int 63(4): 296-9.
Wapniarz, M., Lehmann, R., Randerath, O., Baedeker, S., John, W., Klein, K., Allolio, B. 1994. Precision of dual X-ray absorptiometry and peripheral computed tomography using mobile densitometry units. Calcif Tissue Int 54(3): 219-23.
World Health Organization. 1994. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: report of a WHO study group. Geneva: World Health Organization.
