Executive Summary of the Malaysian Consensus on the Management of Acute and Persistent Hyperkalaemia: A Multidisciplinary Approach

Malaysian Consensus on Managing Hyperkalaemia
Vol. 20 No. 2 : 2025 (693-709)

Lim Soo Kun
Lim Soo Kun
Mohd Rahal Yusoff
Mohd Rahal Yusoff
Shaik Farid Abdull Wahab
Shaik Farid Abdull Wahab
Sunita Bavanandan
Sunita Bavanandan
Chew Soon Ping David
Chew Soon Ping David
Ching Chen Hua
Ching Chen Hua
Siti Suhaila Hamzah
Siti Suhaila Hamzah
Paranthaman Kaneson
Paranthaman Kaneson
Liew Houng Bang
Liew Houng Bang
Prasad Menon
Prasad Menon
Azmee Mohd Ghazi
Azmee Mohd Ghazi
Tan Li Ping
Tan Li Ping
Abstract
Hyperkalaemia (HyperK+) is a potentially life-threatening condition that poses significant challenges in both acute and chronic care, especially for patients with chronic kidney disease, heart failure and diabetes mellitus. While renin-angiotensin-aldosterone system inhibitors (RAASi) are guideline-directed medical therapy known for their cardiorenal benefits, concerns about the increased risk of hyperK+ associated with these medications have hindered their optimal use. Despite these challenges, ambiguity remains regarding the management of hyperK+, highlighting the need for a standardised approach. This Malaysian consensus provides evidence-based guidelines for managing acute and persistent hyperK+ tailored to the local healthcare context.

Keywords : Cardiorenal syndrome; emergency medicine; hyperkalaemia; sodium zirconium cyclosilicate,

Correspondance Address
Lim Soo Kun. Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Wilayah Persekutuan, Malaysia. Tel: +603 79492555 Email: limsk@ummc.edu.my


All K+ levels are in mmol/L. *RAAS-i = ACE-i/ARB, ARNI and MRA. [ACE-i: angiotensin-converting enzyme inhibitor; AKI: acute kidney injury; ARB: angiotensin II receptor blocker; ARNI: angiotensin receptor-neprilysin inhibitor; CKD: chronic kidney disease; CPS: calcium polystyrene sulfonate; ECG: electrocardiogram; ED: emergency department; HF: heart failure; K+: potassium; MRA: mineralocorticoid receptor antagonist; NSAID: non-steroidal anti-inflammatory drug; PO: orally; TDS: three times daily; RAAS-i: reni