Low Grade Papillary Nasopharyngeal Adenocarcinoma (LGPAC) is a very rare tumour of mucosal origin compared to a higher incidence of well differentiated keratinized/non-keratinized nasopharyngeal carcinoma. It is an epithelial tumour with glandular differentiation. Its papillary figure seen histologically, is also seen in metastatic papillary thyroid carcinoma. This has caused a significant challenge to the Pathologist to differentiate primary papillary nasopharyngeal adenocarcinoma and metastatic tumour. Thyroid Transcription Factor-1 (TTF-1) is also expressed in subsets of papillary nasopharyngeal adenocarcinoma, which is valuable as a diagnostic tool. LGPAC is a benign-like malignant neoplasm. An early diagnosis with a complete tumour removal via conventional excision or endoscopic approach has offered a good prognosis with low risk of recurrence.
The Rare Primary Low Grade Papillary Adenocarcinoma of Nasopharynx: A Diagnostic Challenge and Management
Author
Abstrak
Papillary Nasopharyngeal Adenocarcinoma Gred Rendah (LGPAC) adalah sejenis tumor berasal dari mukosa yang jarang berlaku berbanding kanser nasofarinks jenis “keratinized”. Secara histology, terdapat diferensiasi jenis papillari yang juga boleh didapati dalam kes metastatik karsinoma papilari tiroid. Keadaan ini menyebabkan cabaran bagi pihak patologi untuk membezakan antara kes primari atau metastatik. Thyroid Transcription Factor-1 (TTF-1) diekspreskan dalam subset Papillary Nasopharyngeal Adenocarcinoma dan ini merupakan alat diagnostic yang berguna. LGPAC adalah tumour malignan bersifat benign. Diagnosis awal beserta pembedahan membuang keseluruhan tumour melalui cara konvensional atau endoskopik boleh memberikan prognosis bagus dan risiko berlakunya lagi tumour ini adalah rendah.
Kata kunci
Abstract
Keywords
|
|
|
Related Images
