Coronavirus disease 2019 (COVID-19) vaccines have been introduced to the masses for just over two years. Majority reported adverse events post vaccination are minor side effect such as pain or inflammation at local injection site. Serious side effects such as thrombotic events or myocarditis are rarely reported. Cerebral venous sinus thrombosis (CVST) is a thrombotic complication that may occur within one to two weeks from vaccine administration. We illustrated a case from our centre involving a healthy young lady who presented with headache and an episode of seizure following by vaccination. She was concurrently diagnosed with CVST and COVID-19 infection later with the aid of neuroimaging. The patient's normal platelet count made the diagnosis of vaccine induced immune related thrombotic thrombocytopenia unlikely. While serious adverse events are reported, such as our case, this should not support the growing vaccine hesitancy among the public as its benefits still greatly outweigh its risk at this juncture.
Extensive Cerebral Venous Thrombosis following by COVID-19 Vaccine with Concomitant COVID-19 Infection
Author
Abstrak
Vaksin penyakit Coronavirus 2019 (COVID-19) telah diperkenalkan sejak dua tahun lepas di seluruh dunia. Kebanyakan kesan sampingan yang dilaporkan selepas vaksinasi merupakan gejala ringan seperti sakit otot dan sakit pada tempat suntikan. Kesan sampingan yang serius seperti kejadian trombotik atau miokarditis jarang berlaku. Trombosis sinus vena serebrum (CVST) adalah komplikasi trombotik yang mungkin berlaku dalam tempoh satu hingga dua minggu selepas vaksinasi. Kami ingin melaporkan kes melibatkan seorang wanita muda yang mengalami sakit kepala dan sawan selepas vaksinasi. Keputusan imbasan otak menunjukkan CVST dan juga didiagnos dengan jangkitan COVID-19. Pesakit ini mempunyai platelet yang mencukupi. Oleh demikian, punca kejadian trombosis tidak berkaitan dengan tindak balas immuniti vaksin dengan platelet yang rendah Walau bagaimanapun, kejadian kesan sampingan tidak patut dijadikan sebagai alasan untuk meragui vaksinasi kerana faedahnya melebihi daripada risikonya pada ketika ini.
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