Osteoarthritis is the most common degenerative joint disease that develops in the elderly. The worldwide prevalence continues to rise, leading to pain and disability in older ages. Osteoarthritis can be diagnosed by using plain film X-ray combined with clinical appearance and structural features. The imbalance between cartilage synthesis and degradation has been explained in the development of osteoarthritis, which is associated with chondrocyte death. There are many cytokines and biological markers related to the disease. The present review provides a background and discusses the known biological markers that are related to developing osteoarthritis. These include advance glycation end products, glutathione and glycosaminoglycans.
Biological Markers Associated Osteoarthritis
Author
Abstrak
Osteoartritis ialah penyakit degeneratif sendi yang kerap berlaku pada warga tua seluruh dunia. Prevalen penyakit ini terus meningkat dan menjadi penyebab utama kesakitan serta hilang upaya pada umur tua. Osteoartritis boleh didiagnos melalui X-ray filem ringkas berserta tanda klinikal dan ciri-ciri struktur. Ketidakseimbangan antara sintesis dan degradasi kartilaj telah dinyatakan terlibat dengan perkembangan osteoarthritis, yang dikaitkan dengan kematian kondrosit. Walaupun terdapat banyak sitokin dan petanda biologi yang berkait dengan penyakit ini, ulasan ini akan menyediakan latarbelakang dan perbincangan petanda-petanda biologi yang diketahui terlibat dengan perkembangan osteoarthritis termasuk hasil akhir ‘glycation’ lanjutan, glutation dan glikosaminoglikan.
Abstract
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