The t(8;21)(q22;q22) is a frequently occurring aberration in acute myeloid leukemia (AML) (18-20%) and usually correlate with French-America-British (FAB) M2 subtype. Several studies showed that patients carrying this abnormality demonstrated good response to standard chemotherapy but also have a high incidence of disease relapse. Trisomy 4 is a rare and specific chromosomal abnormality occurring in AML M2 or M4 of the FAB subtypes. We report a case of a 33-year-old female with an apparently clinical and hematologic diagnosis of acute promyelocytic leukemia (APL) in whom cytogenetic analysis revealed an abnormal karyotype with trisomy 4, in addition to t(8;21). Trisomy 4 and t(8;21) in a patient with AML is rare. The significance of t(8;21) with trisomy 4 in AML are unclear but patients bearing this abnormality are associated with a poor prognosis.
Concomitant t(8;21) And Trisomy 4 in a Patient with Acute Myeloid Leukemia (AML)
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Abstrak
Aberasi t(8;21)(q22;q22) kerap berlaku pada leukemia myeloid akut (18-20%) dan selalunya dikaitkan dengan sub-jenis ‘French-America-British (FAB) M2’. Aberasi trisomi 4 jarang berlaku dan ia adalah keabnormalan spesifik yang berlaku pada AML M2 atau M4. Kami melaporkan satu kajian kes daripada seorang wanita berumur 33 tahun di mana diagnosa klinikal dan laporan hematologi menunjukkan leukemia promyelosit akut (APL). Ujian sitogenetik pesakit menunjukkan keabnormalan kromosom melibatkan aberasi t(8;21) dan trisomi kromosom 4. Kehadiran trisomi 4 dengan t(8;21) dalam kes AML jarang berlaku. Kehadiran trisomi 4 dengan t(8;21) tidak mempunyai signifikan yang jelas tetapi ia berkait dengan prognosis yang kurang baik.
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